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2月19 by tattyan細胞間情報伝達を大別すると、接合分子による直接伝達とサイトカインという細胞間情報伝達物質による間接的伝達になる。接合分子は細胞膜表面にあり、リガンドという結合相手と結合し、情報を受け取り、細胞を活性化させる。また、その結合は弱いので、情報を得ると、すみやかに離れ、次々に各種のリガンドと結合することができるので、様々な情報を受け取ることができる。更に、接合分子は、Ｉｇループと呼ばれる免疫グロブリンに似た構造を持つ免疫グロブリンスーパーファミリーと、リガンドが細胞外に結合すると細胞内の骨格成分が一体化することで細胞を活性化させるインテグリンファミリーと、レクチン様の接合分子で、特定の糖鎖をリガンドとするセレクチンファミリーとに別けられる。免疫グロブリンスーパーファミリーには、ヘルパーＴ細胞の細胞膜表面にあるＣＤ４、あるいはキラーＴ細胞にあるＣＤ８と呼ばれる抗原があり、主に抗原の識別を行っている。ＨＩＶはＣＤ４に接合し、免疫不全を起こすことが知られている。インテグリンファミリーには、抗原標示細胞やＢ細胞、血管内皮細胞にあるＬＦＡ－１や、白血球表面にある補体Ｃ３ｂの受容体であるＭａｃ－１・ＣＲ３があり、白血球やＢ細胞、単球などの働きを促進させている。つまり、補体Ｃ３ｂが細菌などと結合すると，この複合体は貪食細胞に捕食されやすくなる。これをオプソニン作用と呼んでいる。セレクチンファミリーには、白血球に発現するＬ－セレクチンと血管内皮細胞に発現するＥ－セレクチンやＰ－セレクチンがあり、Ｐ－セレクチンは血小板による血管内皮細胞の損傷を修復している。一方、細胞間情報伝達物質であるサイトカインは、産生する細胞に自己分泌したり、近傍の細胞に傍分泌したりして、細胞のサイトカインレセプターと結合することにより情報伝達し、細胞の増殖や分化、機能調節などをしている。サイトカインの特徴としては、ひとつのサイトカインは複数の情報を伝達する多能性や、複数のサイトカインが同じ情報をもたらす重複性が知られている。また、サイトカインは接合分子による直接伝達を促進させたり、自身の分泌が接合分子により促進されたりしている。サイトカインには、炎症反応を促進させる炎症性サイトカイン、炎症反応を抑制させる抗炎症性サイトカイン、免疫細胞の増殖や分化、活性化を行う免疫調整性サイトカイン、幹細胞の増殖因子となる造血性サイトカイン、白血球の走行性を促進させるケモカインが知られている。また、その中で、遺伝子が同定され、同一性が確立されたサイトカインをインターロイキンと呼び、番号により区別されている。ＩＬ－１(リンパ球活性化因子)、ＩＬ－２(Ｔ細胞増殖因子)、ＩＬ－４(Ｂ細胞増殖因子)、ＩＬ－６(Ｂ細胞分化因子)、ＩＬ－８(好中球活性化ポリペプチド１)、ＩＬ－１０(サイトカイン合成阻止因子)、ＩＬ－１２(ＮＫ細胞刺激因子)などがある。更に、腫瘍壊死因子であるＴＮＦ－αやＴＮＦ－βがあり、腫瘍細胞に障害をもたらすサイトカインとして知られている。
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21 août 2015 @ 07:51
Thème mythique de la maison Cartier.Je la verrai bien portée par la sheikha Mozah…
et même par moi si on me l’offrait.
Répondre
23 août 2015 @ 10:31
Je la prends tout de suite! Cette broche à mon avis est plutôt Wallis que Mozah, encore que je l’ai vu porter quelques créations de Cartier dans la mouvance Art Déco que j’ai adorées! Heureusement que nos goûts diffèrent, les choses seraient si monotonnes
Bon Dimanche
Répondre
21 août 2015 @ 09:09
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21 août 2015 @ 15:51
Je la veux ! Entre félins , le courant passe bien !
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22 août 2015 @ 07:47
Bien vrai,ma Mie Flabemont! ;-))
A vous tendres ron-rons!!
Répondre
22 août 2015 @ 14:21
A vous de même , ma mie !
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23 août 2015 @ 10:33
Pas question, jolie chatte, je vous bats sur le nombre de félins:-)
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23 août 2015 @ 21:09
Parce que c’est vous , d’accord ! Mais la prochaine fois , j’aurai la priorité , n’Est-ce pas ?
Répondre
24 août 2015 @ 19:45
Mais bien sur…
21 août 2015 @ 09:48
Trop « tape-à-l’oeil » et pas raffiné,à mon gout.
Répondre
21 août 2015 @ 12:17
Aucune panthère n’atteint la perfection de celle que la duchesse de Windsor possédait, quoiqu’on pense de celle-ci (la duchesse, pas la panthère :-))
Répondre
21 août 2015 @ 18:53
C’est bien le type de broche qui porterait la Sheikha Mozah, mais je n’aime pas trop ce style de bijou…..
Répondre
21 août 2015 @ 19:15
Magnifique travail, du grand art. Mais pas à mon goût, alors pas de regret de ne pouvoir l’acheter.
Répondre
21 août 2015 @ 20:38
Le souvenir de Wallis est encore, à mes yeux, trop proche de ce thème pour que je puisse appécier ce genre de bijou.
Répondre
21 août 2015 @ 22:15
Plutôt objet de vitrine que portée en broche.
Répondre
22 août 2015 @ 14:25
Même dans une vitrine je n’aime pas !
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22 août 2015 @ 15:28
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24 août 2015 @ 09:01
Moi j’adore…VC&A avait créé dans ce thème une collection féérique,il y a quelques années…
Répondre